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Our Clinical 
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In vitro

The first stage of most drug development starts with a simple question in a simple system. We can develop cell models specific to your research question. Our expertise in cell-based assays can assess the efficacy and toxicity of your drug. We offer a full range of lab techniques from PCR, qPCR, ELISA, Western blot, to assays for toxicity, apoptosis, proliferation and metabolic status to investigate mechanisms involved your target or drug of interest.

Transgenic Technologies

Invariably, research programmes are time critical and require precision and quality. Our suite of transgenic technologies including rederivation, cryopreservation, rapid colony expansion ensure the highest welfare standards and scientific excellence in the in vivo model systems we run. We can rederive mice to SOPF status (removal of viruses, bacteria and other endo- or exo- parasites). Cryopreserving mouse models removing unnecessary breeding, risk of disease, erroneous breeding, loss of fecundity or unforeseen disasters including fire and flooding. And in vitro fertilisations allows rapid expansion of mouse colonies to initiate in vivo studies quickly and efficiently.

Novel model generation

Genetically-altered rodents and cells represent an ever-growing link between understanding the cause of human disease and effective therapeutic development. We offer a full range of capabilities to create knockout, conditional, reporter and humanised genetically altered mice and cells in culture, including gene-modification of existing knockouts. Our highly experienced PhD level staff, ensure fast and efficient delivery of customised projects according to your research needs.

Preclinical

Genetically-altered rodents and cells represent an ever-growing link between understanding the cause of human disease and effective therapeutic development. We offer a full range of capabilities to create knockout, conditional, reporter and humanised genetically altered mice and cells in culture, including gene-modification of existing knockouts. Our highly experienced PhD level staff, ensure fast and efficient delivery of customised projects according to your research needs.

End-to-end management

The key to any successful research project lies in careful planning and an understanding of the limitations of various approaches available i.e. choosing the most suited strategy for your research question. We are happy to provide advice at all stages of your project, whether only considering in vitro investigation as a possible avenue or requiring complete pre-clinical study implementation.

Novel model generation (CRISPR/Cas9)

Genetically-altered animals and cells represent an ever-growing link between understanding the cause of human disease and effective therapeutic development. We offer a full range of capabilities to create knockout, conditional, reporter and humanised genetically altered animals and cells in culture, including gene-modification of existing knockouts. Our highly experienced PhD level staff, ensure fast and efficient delivery of customised projects according to your research needs.